Elevated CD4+ memory T-cells enable immune response to neoadjuvant atezolizumab in non-squamous NSCLC
My summer research from 2023 uses statistical analysis, GSEA, and TIMER2 immune deconvolution to investigate immune response. 
Posts by Collection
portfolio
Dynamical systems approaches for deep learning
My undergraduate senior thesis from 2024 reimagines neural network designs as discrete dynamical systems, and investigates the effects of sparse and low-rank matrices on iterative network performance. 
publications
Dual CDKN2A/MTAP loss compared to CDKN2A loss alone and response to immune checkpoint inhibitors (ICI) in advanced solid tumors
Published in Journal of Clinical Oncology, 2022
This paper investigates the impact of CDKN2A and MTAP genomic alterations on the response to immune checkpoint inhibitors in cancer patients and finds that the co-occurrence of MTAP/CDKN2A alterations is associated with poorer outcomes, particularly in urothelial carcinoma and melanoma, accompanied by lower tumor-infiltrating lymphocyte density in melanoma samples with both alterations.
Recommended citation: Adib, E., Nassar, A., El Zarif, T., Kale, N., Rakaee, M., Mouhieddine, T. H., Abou Alaiwi, S., Freeman, D., Labban, M., Akl, E., Haddad, R. I., Hodi, F. S., Sonpavde, G. P., Giannakis, M., Braun, D. A., Gusev, A., Choueiri, T. K., Overstreet, E., Stone, E., & Kwiatkowski, D. J. (2022). "Dual CDKN2A/MTAP loss compared to CDKN2A loss alone and response to immune-checkpoint inhibitors (ICI) in advanced solid tumors." Journal of Clinical Oncology, 40(16_suppl), 2622–2622. https://doi.org/10.1200/jco.2022.40.16_suppl.2622
Enzyme-mediated depletion of methylthioadenosine restores T cell function in MTAP-deficient tumors and reverses immunotherapy resistance
Published in Cancer Cell, 2023
Using clinical data on human melanoma and urothelial carcinoma and murine models, we show that MTAP deletion and accumulation of MTA lead to an immune cold microenvironment through effects on both PRMT5 and adenosine receptors.
Recommended citation: Gjuka, D., Adib, E., Garrison, K., Chen J., Zhang Y., Li W., Boutz D., Lamb C., Tanno Y., Nassar A., Zarif T., Kale N., Rakaee M., Mouhieddine T., Alaiwi A., Gusev A., Rogers T., Gao J., Georgiou G., Kwiatkowski D., Stone E. (2023). "Enzyme-mediated depletion of methylthioadenosine restores T cell function in MTAP-deficient tumors and reverses immunotherapy resistance." Cancer Cell, 41. 1-14. https://doi.org/10.1016/j.ccell.2023.09.005
talks
Talk 1 on Relevant Topic in Your Field
Published:
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Conference Proceeding talk 3 on Relevant Topic in Your Field
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teaching
Teaching experience 1
Undergraduate course, University 1, Department, 2014
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Teaching experience 2
Workshop, University 1, Department, 2015
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